Can trigger independently with messages in plugin registration tool configuration.
Cannot trigger independently without a parent OOB workflow.
More Triggers available in plugin registration tool.
does not support more events except Create, Update, Status Change, Delete and On assign
Can be configured either Sync/Async
Can run only when used as a sept in OOB workflow
Cannot be called on-demand only triggers on some events
Can be called on-demand to execute
Always triggered by the messages to which they’re registered, though some Messages allow limiting execution based on whether certain attributes have been passed into the Message.
Limited to automatically execute within specific organizational scopes (i.e. Org, BU, Parent and Child BUs, or for the Owner only).
These are the key comparisons between Custom Workflow and Plugins